Chinese researchers have unveiled significant insights into the remarkable longevity and disease resistance of naked mole rats. This discovery highlights a unique version of a protein involved in DNA repair that is similarly present in humans. The research team, spearheaded by scientists from Tongji University in Shanghai, demonstrated that by introducing this modified protein into flies and mice, they could significantly reduce genetic damage associated with aging and consequently extend lifespan.
The findings of this study, which were published in the peer-reviewed journal Science on October 9, suggest that the exceptional longevity observed in naked mole rats could pave the way for innovative therapeutic strategies aimed at combating aging in humans. As burrowing rodents, naked mole rats can live for up to 37 years, a remarkable lifespan for mammals of their size.
The research team stated, “Our work provides a molecular basis for how DNA repair is activated to contribute to the exceptional longevity during evolution in naked mole rats.” Their exploration into the mechanisms behind aging and longevity not only sheds light on the unique biology of these rodents but also opens potential avenues for enhancing human health and lifespan.
