Florence Healthcare has announced a significant achievement in clinical trial operations by establishing the largest network in the industry, connecting over 65,000 research sites with more than 600 sponsors across 90 countries. This advancement sets a new standard for initiating studies powered by artificial intelligence (AI), workflow automation, and operational risk management, according to a statement made on October 23, 2025.
Recognized as the leading clinical trial technology for six consecutive years, Florence continues to enhance the initiation speed, automate workflows, and manage operational risks within sponsors” study portfolios. “Florence was created to bring sponsors and sites together in a shared operational space,” stated Ryan Jones, CEO of Florence Healthcare. “We first fully digitized study initiation to eliminate manual bottlenecks and paper workflows. Now, we are using AI to accelerate speed and enhance intelligence across 65,000 research sites globally, providing sponsors with portfolio-level operational visibility that allows them to anticipate risks, act on data, and execute effectively on the ground.”
The lack of digitalization in many areas of the sector is costly. Currently, only 30 percent of research sites worldwide utilize an electronic Investigator Site File (eISF), leaving around 200,000 sites reliant on inefficient paper-based processes for startup, document collection and storage, regulatory management, monitoring, and closure. This digital gap is estimated to cost sponsors about 1 million dollars per study in lost productivity, rework, and quality compliance risks.
Florence is addressing this digital divide through its rapidly growing clinical research network. By digitizing 100 percent of operational workflows, Florence is setting the standard for startup speed, cost reduction, and risk management. The results are compelling:
- Startup operations are up to 70 percent faster compared to the average startup time at a top 10 global pharmaceutical sponsor.
- Annual operational cost savings of around 141 million dollars have been achieved by automating center preparation workflows, based on active daily users and total hours saved annually across the Florence network.
- Quality control approval rates for the electronic Trial Master File (eTMF) improved from 65 percent to 98.7 percent, thanks to integrated operational audits and automatic compliance checks that help manage risk.
Florence is also incorporating AI throughout the study lifecycle to unlock data-driven operational insights, recommend optimal next steps, strengthen risk control, and enhance operational efficiency. The platform”s extensive site intelligence network enables sponsors and Contract Research Organizations (CROs) to identify the most qualified sites based on therapeutic area, geography, and performance. AI-assisted feasibility surveys facilitate faster and more accurate completions.
Additionally, AI-enabled recruitment and document sharing between the eTMF and eISF streamline essential document exchanges, while generative AI functions for contract markup and comparison significantly shorten review cycles, enabling terms to be compared in seconds and drastically reducing activation time.
AI-driven monitoring reports detect early risk signals from operational audit logs and site data, providing real-time visibility that allows for proactive intervention. These insights minimize the need for on-site visits, ensuring that trials remain on schedule. Collectively, these innovations empower sponsors and CROs to transition from manual oversight to intelligent execution across global study portfolios.
Through its open API network, Florence is rapidly integrating and expanding its trial operations capabilities with other partnered eClinical systems. Florence AI operates at the speed of trust, ensuring that each study remains fully compliant with FDA, EMA, HIPAA, GDPR, EU Annex 11, ICH E6 (R3), and GCP standards. All new capabilities are expected to be available by December 2025.
Florence will unveil its new capabilities at the Research Revolution 2025, the company”s annual global event taking place from October 26 to 28, 2025, which brings together sponsors, CROs, and research sites. To join the global revolution and view the event live, visit researchrevolutionsummit.com/live.
About Florence Healthcare: Florence is a platform specifically designed to connect sponsors and sites to accelerate clinical trials, enhance operational capacity, and mitigate risk. Scalable by design, Florence optimizes workflows, improves collaboration, and provides real-time visibility throughout studies, enabling research teams to advance more quickly, remain inspection-ready, and increase trial productivity with fewer resources.
Contact Information: Florence Healthcare
Contact Name: Seema Sheth-Voss
Title: Vice President of Marketing
Phone: (888) 829-0896
